Antimicrobial resistance in streptococcus pneumoniae, taiwan. Antibioticresistant invasive pediatric streptococcus. Mar 01, 2002 drug resistant streptococcus pneumoniae drsp strains, however, have steadily increased in prevalence. Soon after mainstream antibiotic usage, multiresistant pneumococcal clones emerged and disseminated worldwide.
Heffelfinger jd, dowell sf, jorgensen jh, klugman kp, mabry lr, musher dm, et al. The past two decades have seen an alarming worldwide increase in the incidence of drug resistant s. Thus, the medical profession had a rude awakening in 1977 and 1978 when outbreaks of infection due to antibiotic resistant. Search terms included azithromycin, zithromax, resistance, resistant, and tra. Dedicated prevention and infection control efforts in the u. Nasopharyngeal carriage of drugresistant streptococcus. Drsp is now common throughout the united states, and physicians are questioning. We evaluated the circulation of spn serotypes and antimicrobial susceptibility among preschool children in lithuania before the. Distinct evolutionary dynamics of horizontal gene transfer in. Mar 20, 2018 vaccination is an important tool for decreasing the spread and disease burden of the widespread bacterial pathogen streptococcus pneumoniae. Streptococcus pneumoniae is one of the most clinically significant pathogens with emerging antibiotic resistance. Here we report a case of bacteremic pneumonia caused by an extremely drug resistant strain of streptococcus pneumoniae, nonsusceptible to at least one agent in all classes but vancomycin and linezolid, posing an important new public health threat in our region. Management of communityacquired pneumonia in the era of pneumococcal resistance. However, current vaccines target only a subset of pneumococcal serotypes, and the nonvaccine types often remain at high frequencies after vaccination.
This pdf is available for free download from a site hosted by medknow publications. Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis1. Nosocomial outbreak of multiresistant streptococcus. We performed a surveillance study in isolated rural populations of healthy children to estimate the prevalence of pneumococcal resistance and to contrast factors that predict pneumococcal carriage with those that specifically predict resistant pneumococcal carriage. Antibioticresistant pneumococcal isolates also were compared with international clones of multiply resistant s pneumoniae. Extensively drugresistant streptococcus pneumoniae, south.
Streptococcus pneumoniae, invasive disease nondrug. Asymptomatic nasopharyngeal colonization is a predisposing factor for pneumococcal infection 2. Pdf aggregated antibiograms and monitoring of drug. Since the late 1970s, penicillin resistant pneumococci prp have become prevalent worldwide, and pneumococcal strains with decreased sensitivity to benzylpenicillin, as well as other antimicrobial agents, have been reported from many countries. Evolution of streptococcus pneumoniae serotypes and antibiotic resistance in belgiumupdate 199498 previous article use of shortterm culture for identification of mycobacterium avium subsp. We will delve into the mechanism of actions, microbiological spectrum, and, where available, the pharmacokinetics, safety pro. Official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern. Antibiotic resistant international clones of streptococcus pneumoniae are increasingly reported in different parts of the world. We derived estimates of healthcare utilization and cost in 2012. Pdf antimicrobial resistant streptococcus pneumoniae.
The prevalence of drug resistant streptococcus pneumoniae in atlanta. Antimicrobial resistant streptococcus pneumoniae in a tertiary care. Streptococcus pneumoniae drsp due, in large part, to increased use of. The emergence of resistance in the drugs used to treat infections with this organism is of major public health significance. Nosocomial outbreak of drugresistant streptococcus pneumoniae. Having a risk factor for drug resistant streptococcus pneumoniae disease makes the chances of getting a condition higher but does not always lead to drug resistant. Multidrugresistant streptococcus pneumoniae from india the. Drug resistant streptococcus pneumoniae drsp strains, however, have steadily increased in prevalence. Drugresistance in streptococcus pneumoniae isolates among. Several surveillance programs that span numerous countries indicate that. Strong evidence supports an association between antibiotic use and resistance in hospitals 2,3. Pneumococci with intermediate penicillin resistance lpr have been recovered from patients for 15years. Review article antibiotic resistance in streptococcus. Streptococcus pneumoniae is a topic covered in the johns hopkins abx guide.
Streptococcus pneumoniae infections are among the leading causes worldwide of. Risk factors for drug resistant streptococcus pneumoniae disease are factors that do not seem to be a direct cause of the disease, but seem to be associated in some way. A surveillance case definition is a set of uniform criteria used to define a disease for public health surveillance. In some cases, nonvaccine types display a disconcerting increase in antibiotic resistance frequencies. Original contributions evaluation of innovative surveillance for drug resistant streptococcus pneumoniae joseph f.
However, one strain was multidrug resistant, exhibiting. In some cases, nonvaccine types display a disconcerting increase in antibiotic resistance. Vaccination is an important tool for decreasing the spread and disease burden of the widespread bacterial pathogen streptococcus pneumoniae. Original article increasing prevalence of multidrug. International prevalence and risk factors evaluation for drug. Emergence of vancomycin tolerance in streptococcus pneumoniae. Isolates were tested for antibiotic susceptibility, serotyped, and genotyped by random amplified polymorphic dna. We estimated the annual burden and incremental costs attributable to antibiotic resistance in pneumococcal pneumonia. Publications home of jama and the specialty journals of the. Multidrugresistant streptococcus pneumoniae causing invasive pneumococcal disease isolated from a paediatric patient. Streptococcus pneumoniae pneumococcus, the most common cause of bacterial respiratory tract infections in children and adults, was susceptible to virtually all antibiotics used in treating such infections until outbreaks of infection due to antibiotic resistant pneumococci were recognized in south africa in the late 1970s.
Streptococcus pneumoniae resistant to penicillin, non. The emergence of antimicrobial resistance threatens the successful treatment of pneumococcal infections. Public health impact drugresistant streptococcus pneumoniae. Aggregated antibiograms and monitoring of drugresistant streptococcus pneumoniae article pdf available in emerging infectious diseases 99. Evaluation of innovative surveillance for drugresistant. Drugresistant streptococcus pneumoniae clinical infectious. Reporting requirements references disease case report cd1 pdf format word format streptococcus pneumoniae. Antibiotic therapy and acute outcome of meningitis due to streptococcus pneumoniae considered intermediately susceptible to broadspectrum cephalosporins. Surveillance worksheet cdc pneumococcal conjugate vaccine failure case report cdc 52.
Macrolide resistance among invasive streptococcus pneumoniae. To view the entire topic, please sign in or purchase a subscription. This study assessed current levels of penicilin resistance among streptococcus pneumoniae causing pneumonia in spanish middle age and older adults. Management of pneumococcal infections used to be relatively straightforward, and penicillin generally was the antibiotic of choice. However, since the 1990s there has been a significant increase in drugresistant. Pneumococcal isolates not susceptible to penicillin first appeared in taiwan in 1986. Report of a working group summary streptococcus pneumoniae is a leading cause of morbidity and mortality in the united states, resulting each year in an estimated 3,000 cases of meningitis, 50,000 cases of bacteremia, 500,000 cases of pneumonia, and 7,000,000 cases of otitis media.
Biological and epidemiological features of antibiotic. Streptococcus pneumoniae is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Antimicrobial resistance in invasive and colonising streptococcus pneumoniae in north india r goyal, np singh, m kaur, v talwar abstract the present study was done to detect the antibiotic resistance in s. Defining the public health impact of drug resistant streptococcus pneumoniae report of a working group appendix laboratorybased surveillance system mmwr 45rr1. Defining the public health impact of drugresistant. Action plan for drugresistant streptococcus pneumoniae. The prevalence of drugresistant streptococcus pneumoniae in. International prevalence and risk factors evaluation for. The emergence of multiple drug resistance has complicated the empirical treatment of pneumococcal infections. Multidrugresistant streptococcus pneumoniae causing invasive. They are usually found in pairs and do not form spores and are nonmotile. By contrast, the relationship between antibiotic consumption and resistance has been more difficult to establish for the outpatient setting, although some data. In more than 30% of infections, the bacteria are resistant to one or more clinically relevant antibiotics.
Taiwan has one of the highest levels of antibiotic resistant pneumococcus in the world. Streptococcus pneumoniae, drug resistant invasive disease drsp streptococcus pneumoniae recommend on facebook tweet share compartir national notifiable time periods. Molecular mechanisms and epidemiology of resistance in. Streptococcus pneumoniae remains a major cause of infection in both children and adults, annually resulting in significant morbidity and mortality. Attributable healthcare utilization and cost of pneumoniae. Clinical features and outcomes of 5 patients with extensively drugresistant streptococcus pneumoniae from samsung medical center, seoul, south korea, 20112012. Macrolide resistance mechanisms include ribosomal target site alteration, alteration in antibiotic transport, and modification of the antibiotic. Resistance of streptococcus pneumoniae to betalactam. Drsp is now common throughout the united states, and physicians are questioning how best to approach this epidemic.
Both highlevel and lowlevel resistance to macrolides is increasing in pneumococci globally. Streptococcus pneumoniae, drug resistant invasive disease drsp streptococcus pneumoniae 1995 case definition recommend on facebook tweet share compartir note. Pdf antibiotic resistance in streptococcus pneumoniae. Multidrugresistant streptococcus pneumoniae from india. Impact of pneumococcal conjugate vaccine on infections. Vaccination can drive an increase in frequencies of. High carriage rates of prp in the community have been shown to result in an increased incidence of clinical infection 4, and healthy children. We investigated the spread of these clones through an active surveillance performed at the israeli streptococcal national center during 1998 and 1999. Bacteremic pneumonia caused by extensively drugresistant. Streptococcus pneumoniae is an important cause of morbidity and mortality in both the paediatric and adult population. Pneumococci are a frequent cause of sinusitis and pneumonia. Resistant clones are generated through adaptation to antibiotic pressures imposed while naturally residing within the human upper respiratory.
Macrolide resistance in streptococcus spp the lancet. Management of infections due to antibioticresistant. Appropriate use of antimicrobials for drugresistant. Streptococcus pneumoniae presence and antibiotic resistance detected from nasopharyngeal swabs of participants. Drugresistant streptococcus pneumoniae disease symptoms. Author summary klebsiellla pneumoniae is classified by the world health organization as a priority drug resistant organism because it causes a significant burden of hospital infections that are extremely difficult to treat. This study aimed to define pneumococcal colonization rates, and antibiotic resistance patterns across two periods a decade apart, and also assess the serotypes of colonizing strains in children in the era of early pneumococcal conjugate vaccine uptake. Streptococcus pneumoniae is one of the most common organisms causing upper respiratory, lower respiratory, and invasive infections in children and adults. Streptococcus pneumoniae antigen detection in urine background streptococcus pneumoniae is the most common organism recovered from patients with communityacquired pneumonia cap. Predictive factors for invasive disease due to penicillin resistant streptococcus pneumoniae. Streptococcus pneumoniae, antimicrobial resistance, blood cultures, cerebrospinal fluid, sputum introduction streptococcus pneumoniae is a major bacterial pathogen. Here, wholegenome sequencing was used to demonstrate nosocomial acquisition of antimicrobial resistant sequence type 156 st156 serotype 9v s. Streptococcus pneumoniae was the most frequently identified pathogen in a cohort of patients with community acquired pneumonia cap 2683193 8. The antibiotic that drsp is most commonly resistant to is penicillin, but drsp may also be resistant.
A pneumococcal infection is an infection caused by the bacterium streptococcus pneumoniae, which is also called the pneumococcus. From the beginning of the antibiotic era to the mid1970s, streptococcus pneumoniae pneumococci remained uniformly susceptible to all classes of antibiotics that had been active against the organisms, with the possible exception of tetracycline. Emerging treatment options for infections by multidrug. Lactam resistant streptococcus pneumoniae antimicrobial use and the emergence of antimicrobial resistance with. We derived estimates of healthcare utilization and. International prevalence and risk factors evaluation for drugresistant streptococcus pneumoniae pneumonia article pdf available in journal of infection 794 july 2019 with 67 reads. Jorgensen,4 stephanie hall,4 and william schaffner 2,3. Pdf pneumococci were once among the most highly penicillinsusceptible. Streptococcus pneumoniae, invasive pneumococcal disease ipd table of contents. Drugresistant streptococcus pneumoniae pdf paperity. Macrolide antibiotics are widely used for a range of indications, including pneumonia. Streptococcus pneumoniae, drugresistant invasive disease.
Pneumococcal diseases remain a major cause of morbidity and mortality worldwide. Streptococcus pneumoniae, invasive pneumococcal disease. Clinical implications and treatment of multiresistant streptococcus. It accounts for an estimated 3,000 cases of meningitis, 50,000 cases of bacteremia, 500,000 cases of pneumonia, and more than seven million cases of otitis media annually 1, 2. Streptococcus pneumoniae is a leading cause of illness and death in the united states. In addition, 223,900 cases of clostridioides difficile occurred in 2017 and at least 12,800 people died. Antibiotic resistant streptococcus pneumoniae, particularly penicillin resistant strains, are being identified with increasing frequency. Publications home of jama and the specialty journals of. A global trend of increasing antimicrobial resistance, but with wide variations at national levels, is welldocumented in the literature. Since the first description of infection caused by.
More detailed information about the symptoms, causes, and treatments of drug resistant streptococcus pneumoniae disease is available below. Ho and christian sawicki on electronic databases medline and web of science up to rd of january. Risk factors for drugresistant streptococcus pneumoniae. Streptococcus pneumoniae is a commensal bacterium that normally colonizes the human nasopharyngeal cavity. We thank the department of medical microbiology at imperial college nhs trust. Streptococcus pneumoniae, or pneumococcus, is a grampositive, alphahemolytic under aerobic conditions or betahemolytic under anaerobic conditions, facultative anaerobic member of the genus streptococcus. Management of infections due to antibiotic resistant streptococcus pneumoniae. Streptococcus pneumoniae infections arising in hospitalized patients are often assumed to be sporadic and linked to community acquisition. Evolution of streptococcus pneumoniae serotypes and. Multiple antibiotic resistant strains are widespread, and vancomycin is the antibiotic.
Article antimicrobial resistance in streptococcus pneumoniae. Streptococcus pneumoniae, invasive pneumococcal disease ipd. Streptococcus pneumoniae antigen detection in urine. Drsp were identified in new guinea as early as 1967 5, but medical experts at the time concluded that the microorganisms were not likely to spread and thus posed little threat to the general population, a prediction that turned out to be. Original article increasing prevalence of multidrugresistant. However, outside of the hospital setting this bacterium is also an important cause of severe drug susceptible infections. Increasing prevalence of multidrugresistant streptococcus. Drsp stands for drug resistant streptococcus pneumoniae, a bacterium that has developed resistance to at least one drug that is commonly used for pneumococcal infections. It also is a common cause of bloodstream infections, and ear and sinus infections. Streptococcus pneumoniae, invasive disease non drug resistant child, streptococcus pneumoniae recommend on facebook tweet share compartir national notifiable time periods. Drug resistant streptococcus pneumoniae drsp southern. Limited data are available regarding the current global burden and risk factors associated with drug resistant streptococcus pneumoniae drsp in cap subjects.
Nosocomial outbreak of drugresistant streptococcus. Pdf international prevalence and risk factors evaluation. Trends in penicillin resistance among streptococcus pneumoniae in the united. Streptococcus pneumoniae is the most commonly identified cause of communityacquired pneumonia, accounting for 9% to 55% of cases of communityacquired pneumonia among patients requiring hospitalization. Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with communityacquired pneumonia cap worldwide.
Streptococcus pneumoniae inflicts a huge disease burden as the leading cause of communityacquired pneumonia and meningitis. Once disseminated, it can cause several diseases, ranging from noninvasive infections such as acute otitis media and sinusitis through to invasive infections with higher mortality, including meningitis and septicaemia. Updated data on drug resistance from different populations may be important to recognize changes in disease patterns. Streptococcus pneumoniae, drug resistant invasive disease drsp streptococcus pneumoniae 2007 case definition recommend on facebook tweet share compartir note. High rates of multiple antibiotic resistance in streptococcus. Streptococcus pneumoniae, drugresistant invasive disease streptococcus pneumoniae pneumococci causes many clinical syndromes, depending on the site of infection e. Streptococcus pneumoniae pneumococcus is a leading cause of bacterial pneumonia and meningitis in the united states. Vaccines can reduce pneumococcal resistance in vaccinated and unvaccinated populations by reducing the carriage of. Streptococcal respiratory infection resistant to antibiotics. Antimicrobial susceptibilities of 5 extensively drugresistant streptococcus pneumoniae isolates, seoul, south korea, 20112012. Streptococcus pneumoniae, cross infection, nosocomial, antimicrobial resistance, wholegenome sequencing main text streptococcus pneumoniae is a major cause of communityacquired pneumonia, bacteraemia and meningitis 1.
Background streptococcus pneumoniae is a major cause of illness, and the emergence of drug resistant strains threatens to complicate the management of pneumococcal infections. Other frequent etiologies of cap include mycoplasma pneumoniae, haemophilus influenzae, chlamydophila pneumoniae and respiratory viruses. The sensitivity of streptococcus pneumoniae to penicillin improved from 66% to 100% p. Drug resistant strains complicate clinical treatment and may increase costs. Johns hopkins guide app for ios, iphone, ipad, and android included. Streptococcus pneumoniae is the most frequent isolate from clinical samples of respiratory tract infection, including acute exacerbations of chronic bronchitis and communityacquired pneumonia.